Premature Ejaculation

A new cause for premature ejaculation?

The latest piece of research by Utrecht University shows that quickness of ejaculation in men is determined genetically.

 Neuropsychiatrist Dr Marcel Waldinger, and pharmacological researcher, Paddy Janssen, undertook a study of 89 Dutch men who suffer from premature ejaculation and have published the results in the well known international scientific magazine The Journal of Sexual Medicine.

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The participants in the study were 89 local men who suffer from premature ejaculation in the primary form, that is to say, men who had this problem ever since they became sexually active.

Waldinger explained that men who started suffering from this later on in life were excluded as the results might not have scientific rigor.

There was a control group of 92 men whose results were also taken into account. The experiments were conducted in the menís homes and lasted for a month.

During this period, the female partners used a stopwatch to calculate the time from penetration to ejaculation every time they had sex.

Having received the results, the experimenters could grade the subjects in order of timing. The men also had their genetic framework scrutinized.

It was discovered that, in men who suffer from premature ejaculation, the brain chemical serotonin was less active between the nerves in the sector of the brain that controls the process of ejaculation.

Serotonin is one of the substances linked to sexual activity and appetite. It works by transferring a signal from one brain neuron to another, but due to the minimal activity of serotonin in men with the primary form of premature ejaculation, this signal transfer does not take place as normal.

The experimenters thought that a gene might be responsible for the lack of activity.

A gene has already been discovered, namely 5-HTTLPR, which appears to be responsible for the dosage and activity of serotonin, which of course means that this gene is the one that controls the rapidity of ejaculation.

There are 3 separate types of the gene known as LL, SL and SS. Waldinger and Janssen found that the LL type causes a much more rapid ejaculation. Their calculations show that on average men with LL ejaculate more than twice as fast as men with SS.

Also men with LL ejaculate almost twice as quickly as men with SL. This seems to pinpoint the 5-HTTLPR gene but the researchers are still looking for other genes that might be involved in ejaculation.

It looks like Marcel Waldinger has been proved right because as long ago as 1998, he predicted that both the speed with which men ejaculate and the primary form of premature ejaculation were determined not psychologically but genetically.

The new discovery disproves the theory, which has been commonplace for generations, that the primary form of premature ejaculation is exclusively a psychological disorder. The results of this research confirm the genetic theory and may soon contribute to the use of gene therapy as a treatment for premature ejaculation.

A new cure for premature ejaculation has been announced.

It is known as PSD502, which is the scientific code name for a new topical spray, claimed by the developers to be a safe and effective remedy for premature ejaculation.

The researchers make the observation that PSD502 is a precisely metered aerosol formulation of two commonly used and safe  anesthetics known as lidocaine and prilocaine, both of which are proven, safe and effective, and have the advantage of being an easy to use as a treatment for premature ejaculation.

How does this compare with current products?

One of the current treatments for premature ejaculation is a topical cream containing anesthetics or more familiarly products known as desensitizing agents which act to deaden for a brief while the penile skin and thereby delay a man's orgasm and ejaculation.

They are said to be effective but you need a condom to use them effectively and you have to wash the stuff away before you start making love - and of course there is a reduced sexual sensation which may well impact on pleasure.

Now the researchers have shown that this new topical spray, with an aerosol application formulation of lidocaine and prilocaine, is most effective and also extremely easy to use.

It selectively desensitizes the skin of the penis with the result that it only affects the inner lining of the foreskin and the outside tissue of the glans which in turn means it does not adversely affect the feeling of orgasm and ejaculation.

This new formula can be applied as little as five minutes before sex.

This is how the case study worked. The researchers formed a group of as many as 300 men with premature ejaculation.

They comprised a group of men who had a time between penetration and ejaculation (intravaginal ejaculatory latency time) of a minute or less.

The men were divided into two groups, one of which used the PSD502 spray and the others were given a placebo spray.

The spray was to be applied five minutes before sexual intercourse was due to commence. Both groups had the same average baseline of 0.6 minutes latency time before the man reached orgasm and ejaculated.

After use of the new anesthetic spray, the PSD502 group of men who had been ejaculating quickly improved their performance by as much as three minutes taking them to a latency time of four minutes, while the placebo group (ie the control group, who had no treatment) improved to an average of one minute.

The spray was apparently very well tolerated by both users and partners, with no reports of any kind of systemic or indeed serious or unpleasant effects.

The PSD502 group reported only 2.6 percent of treatment-related adverse effects - the nature of which were not specified in the press release from which this information was taken - and the placebo group reported 1 percent.

The results of the study were described by the spokesman for the American Urological Association, Dr Ira D. Sharlip, who stated the obvious fact that premature ejaculation is one of most common male dysfunctions in our society.

The essence of what he said is that PE happens to at least 20% to 30% of men, and probably many more, of all ages, social status and conditions.

An effective, patient-friendly and simple to use treatment for this condition, which can cause much stress, has been in development for a long time and is much overdue.

This new aerosol spray has the potential to become one of the most powerful and most effective treatments for premature ejaculation. It has rather a lot of points in its favor, making it very attractive to all men around the world with premature ejaculation.

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